top of page

Eremina OE, Eremin DB, Czaja A, Zavaleta C. Selecting Surface-Enhanced Raman Spectroscopy Flavors for Multiplexed Imaging Applications: Beyond the Experiment. J Phys Chem Lett. 2021 Jun 17;12(23):5564-5570. doi: 10.1021/acs.jpclett.1c01504. Epub 2021 Jun 9. PMID: 34105967.


Miyasato, D.L., Mohamed, A.W. & Zavaleta, C. A path toward the clinical translation of nano-based imaging contrast agents. Wiley Interdiscip Rev Nanomed Nanobiotechnol, e1721 (2021).

Burkitt, S., Nanomaterials


Salinas, H., Miyasato, D., Eremina, O., Perez, R., Gonzalez, K., Czaja, A., Burkitt, S. Aron, A. Fernando, A., Ojeda, L.S., Larson, K.N., Mohamed, A.W., Campbell, J.L., Goins, B. A., Zavaleta, C.  A colorful approach towards developing new nano-based imaging contrast agents for improved cancer detection [published online ahead of print, 2020 Aug 19]. Biomater Sci. 2020;10.1039/d0bm01099e.


Campbell, J.C., Burkitt, S., Dong, N., Zavaleta C. Nanoparticle Characterization Techniques. Chapter 9. Nanoparticles for Biomedical Applications. 2019.


Davis, R.M., Campbell, J.L., Burkitt, S., Qiu, Z.; Kang, S., Mehraein, M., Miyasato, D., Salinas, H., Liu, J.T.C., Zavaleta, C. A raman imaging approach using cd47 antibody-labeled sers nanoparticles for identifying breast cancer and its potential to guide surgical resection. Nanomaterials 2018, 8.

Zavaleta, C., Ho, D., Chung, E.J. “Theranostic Nanoparticles for Tracking and Monitoring Disease State”. SLAS Technol. (2017). Epub ahead of print.


Campbell, J. L., SoRelle, E. D., Ilovich, O., Liba, O., James M. L., Qiu, Z., Perez, V., Chan, C. T., de la Zerda, A. and Zavaleta, C. (2017). "Multimodal assessment of SERS nanoparticle biodistribution post ingestion reveals new potential for clinical translation of Raman imaging." Biomaterials 135: 42-52.


SoRelle, E. D., Liba, O., Campbell, J. L., Dalal, R., Zavaleta, C. L., de la Zerda, A. A hyperspectral method to assay the microphysiological fates of nanomaterials in histological samples. eLife 5 (2016). 5042654.


Zavaleta, C.*, Sensarn, S.*, Ehud, S., Rogalla, S., Lee, W., Gambhir, S.S., Bogyo, M., Contag, C.H., A clinical wide-field fluorescence endoscopic device for molecular imaging demonstrating cathepsin protease activity in colon cancer. Molecular imaging and biology 18, 820-829 (2016). *co-first authors.


Garai, E., Zavaleta, C.L., Sensarn, S., Loewke, N.O., Rogalla, S., Mandella, M.J.,  Felt, S.A., Friedland, S.,  Liu, J.T., Gambhir, S.S., and Contag, C.H. "A real-time clinical endoscopic system for intraluminal, multiplexed imaging of surface-enhanced Raman scattering nanoparticles." PLoS One 10(4): (2015).


Kempen, P.J., Kircher, M.F., de la Zerda, A., Zavaleta, C.L., Jokerst, J.V., Mellinghoff, I.K., Gambhir, S.S. & Sinclair, R. A correlative optical microscopy and scanning electron microscopy approach to locating nanoparticles in brain tumors. Micron 68, 70-76. (2015).


James, M.L., Shen, B., Nielsen, C.H., Behera, D., Buckmaster, C.L., Mesangeau, C., Zavaleta, C., Vuppala, P.K., Jamalapuram, S., Avery, B.A., Lyons, D.M., McCurdy, C.R., Biswal, S., Gambhir, S.S. & Chin, F.T. Evaluation of sigma-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET. J Nucl Med 55, 147-153. (2014).


*Zavaleta, C.L., *Garai, E., Liu, J.T., Sensarn, S., Mandella, M.J., Van de Sompel, D., Friedland, S., Van Dam, J., Contag, C.H. & Gambhir, S.S. A Raman-based endoscopic strategy for multiplexed molecular imaging. Proc Natl Acad Sci U S A 110, E2288-2297 (2013). *co-first authors


Smith, B.R., Zavaleta, C., Rosenberg, J., Tong, R., Ramunas, J., Liu, Z., Dai, H. & Gambhir, S.S. High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model. Nano Today 8 (2013).


Kempen, P.J., Thakor, A.S., Zavaleta, C., Gambhir, S.S. & Sinclair, R. A scanning transmission electron microscopy approach to analyzing large volumes of tissue to detect nanoparticles. Microsc Microanal 19, 1290-1297 (2013).


Garai, E., Sensarn, S., Zavaleta, C.L., Van de Sompel, D., Loewke, N.O., Mandella, M.J., Gambhir, S.S. & Contag, C.H. High-sensitivity, real-time, ratiometric imaging of surface-enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device. J Biomed Opt 18, 096008 (2013).


Bohndiek, S.E., Wagadarikar, A., Zavaleta, C.L., Van de Sompel, D., Garai, E., Jokerst, J.V., Yazdanfar, S. & Gambhir, S.S. A small animal Raman instrument for rapid, wide-area, spectroscopic imaging. Proc Natl Acad Sci U S A 110, 12408-12413 (2013).


Van de Sompel, D., Garai, E., Zavaleta, C., Gambhir, S. S. A comparison of noise models in a hybrid reference spectrum and principal components analysis algorithm for Raman spectroscopy. Journal of Raman Spectroscopy 44 (6): 841-856 (2013).


Van de Sompel, D., Garai, E., Zavaleta, C. & Gambhir, S.S. A hybrid least squares and principal component analysis algorithm for Raman spectroscopy. Conf Proc IEEE Eng Med Biol Soc 2011, 6971-6974 (2012).


Van de Sompel, D., Garai, E., Zavaleta, C. & Gambhir, S.S. A hybrid least squares and principal component analysis algorithm for Raman spectroscopy. PLoS One 7, e38850 (2012).


Kircher, M.F., de la Zerda, A., Jokerst, J.V., Zavaleta, C.L., Kempen, P.J., Mittra, E., Pitter, K., Huang, R., Campos, C., Habte, F., Sinclair, R., Brennan, C.W., Mellinghoff, I.K., Holland, E.C. & Gambhir, S.S. A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nat Med 18, 829-834 (2012).


James, M.L., Shen, B., Zavaleta, C.L., Nielsen, C.H., Mesangeau, C., Vuppala, P.K., Chan, C., Avery, B.A., Fishback, J.A., Matsumoto, R.R., Gambhir, S.S., McCurdy, C.R. & Chin, F.T. New positron emission tomography (PET) radioligand for imaging sigma-1 receptors in living subjects. J Med Chem 55, 8272-8282 (2012).


Zavaleta, C.L., Kircher, M.F. & Gambhir, S.S. Raman's "effect" on molecular imaging. J Nucl Med 52, 1839-1844 (2011).


Zavaleta, C.L., Hartman, K.B., Miao, Z., James, M.L., Kempen, P., Thakor, A.S., Nielsen, C.H., Sinclair, R., Cheng, Z. & Gambhir, S.S. Preclinical evaluation of Raman nanoparticle biodistribution for their potential use in clinical endoscopy imaging. Small 7, 2232-2240 (2011).


Thakor, A.S., Luong, R., Paulmurugan, R., Lin, F.I., Kempen, P., Zavaleta, C., Chu, P., Massoud, T.F., Sinclair, R. & Gambhir, S.S. The fate and toxicity of Raman-active silica-gold nanoparticles in mice. Sci Transl Med 3, 79ra33 (2011).


Thakor, A.S., Jokerst, J., Zavaleta, C., Massoud, T.F. & Gambhir, S.S. Gold nanoparticles: a revival in precious metal administration to patients. Nano Lett 11, 4029-4036 (2011).


Jokerst, J.V., Miao, Z., Zavaleta, C., Cheng, Z. & Gambhir, S.S. Affibody-functionalized gold-silica nanoparticles for Raman molecular imaging of the epidermal growth factor receptor. Small 7, 625-633 (2011).


Thakor, A.S., Paulmurugan, R., Kempen, P., Zavaleta, C., Sinclair, R., Massoud, T.F. & Gambhir, S.S. Oxidative stress mediates the effects of Raman-active gold nanoparticles in human cells. Small 7, 126-136 (2010).


Zavaleta, C.L., Smith, B.R., Walton, I., Doering, W., Davis, G., Shojaei, B., Natan, M.J. & Gambhir, S.S. Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. Proc Natl Acad Sci U S A 106, 13511-13516 (2009).


Zavaleta, C., de la Zerda, A., Liu, Z., Keren, S., Cheng, Z., Schipper, M., Chen, X., Dai, H. & Gambhir, S.S. Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes. Nano Lett 8, 2800-2805 (2008).


Zavaleta, C.*, Keren, S.*, Cheng, Z., de la Zerda, A., Gheysens, O. & Gambhir, S.S. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proc Natl Acad Sci U S A 105, 5844-5849 (2008). *co-first authors.


De la Zerda, A., Zavaleta, C., Keren, S., Vaithilingam, S., Bodapati, S., Liu, Z., Levi, J., Smith, B.R., Ma, T.J., Oralkan, O., Cheng, Z., Chen, X., Dai, H., Khuri-Yakub, B.T. & Gambhir, S.S. Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat Nanotechnol 3, 557-562 (2008).


Zavaleta, C.L., Goins, B.A., Bao, A., McManus, L.M., McMahan, C.A. & Phillips, W.T. Imaging of 186Re-liposome therapy in ovarian cancer xenograft model of peritoneal carcinomatosis. J Drug Target 16, 626-637 (2008).


Zavaleta, C.L., Phillips, W.T., Soundararajan, A. & Goins, B.A. Use of avidin/biotin-liposome system for enhanced peritoneal drug delivery in an ovarian cancer model. Int J Pharm 337, 316-328 (2007).


Zavaleta, C.L., Phillips, W.T., Bradley, Y.C., McManus, L.M., Jerabek, P.A. & Goins, B.A. Characterization of an intraperitoneal ovarian cancer xenograft model in nude rats using noninvasive microPET imaging. Int J Gynecol Cancer 17, 407-417 (2007).


Bao, A., Phillips, W.T., Goins, B., Zheng, X., Sabour, S., Natarajan, M., Ross Woolley, F., Zavaleta, C. & Otto, R.A. Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection. Int J Pharm 316, 162-169 (2006).

- The Dreamfinder -

“One little spark of inspiration is at the heart of all creation.”


bottom of page